Severe malaria genomics

What host and parasite genetic features cause some kids to get sicker than others upon malaria infection?

  • Diamonds in the rif: Alignment-free sequence analysis reveals strain-transcendent Plasmodium falciparum antigens amidst extensive genetic diversity.

    Under review (Aug 2024)

    Lawton J*, Zhou A*, et al.

    *Contributed equally

  • Distinct Plasmodium falciparum gene expression signatures in severe malaria syndromes occurring concurrently and in isolation.

    Under review (Aug 2024)

    Cummings B, Coulibaly D, Stucke E, Lawton J, et al.

  • Metalloproteases, L-arginine, and glucose transport in severe malaria; analyses of transcriptomic, proteomic, and metabolomic signatures.

    Nature Communications (In press Jul 2024)

    Sobota S, Coulibaly D, Stucke E, Lawton J, et al.

  • ApoE: A new piece to the severe malaria puzzle.

    Pediatric Research (Feb 2024)

    Stucke E, Lawton J, and Travassos M

Malaria seroepidemiology

How do kids acquire antibodies against malaria, and do they protect against severe malaria?

  • Malian children with hemoglobin C or S trait have reduced serological responses to particular extracellular PfEMP1 domains, but not intracellular PfEMP1 domains, RIFINs, or STEVORs.

    Journal of Infection (In press Aug 2024)

    Bailey R, Lawton J, et al.

  • Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s.

    mSphere (Sep 2023)

    Tewey M, Coulibaly D, Lawton J, et al.

HIV epidemiology and continuum of care

How can we eliminate barriers preventing African adults from managing their HIV infections?

  • Effect of Test and Treat on clinical outcomes in Nigeria: a national retrospective study.

    PLOS ONE (Aug 2023)

    Lavoie MC, Ehoche A, Blanco N, El-Imam I, Oladipo A, Dalhatu I, Odafe S, Adebajo S, Nh A, Rapoport L, Lawton J, et al.

  • Prevalence of HIV drug resistance in Nigeria: results from a cross-sectional, population-based survey of Nigerian adults with unsuppressed viral load.

    AIDS (Feb 2023)

    Aliyu G, Lawton J, Mitchell A, Abimiku A, et al.

  • Individual and Household Factors Associated with Non-disclosure of Positive HIV Status in a Population-Based HIV Serosurvey.

    AIDS (Jan 2023)

    Lawton J, Lavoie MC, Charurat M, et al.